So this is a big one and maybe a bit controversial - today you can tab across columns that have data in them but you have to click to enter into the column, make updates and hit save.  So if you have 6 pieces of information to enter you have 6 clicks aside from having to click to get into the column.  It would be much easier if we could just tab across the columns and then type in the edits and save the changes on the object instead of each and every column.  

The less typing we have to d and the faster we can update the data the better the solution.