Campaign selection when you have multiple contacts

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I represent multiple companies and I filter by either an account number or if they are a lead for a company. My problem is when I go to send campaign. It sends to all contacts of the company that match the filiter. Example I represent one company for shoes and another for a sock manufacturer. But since they match the filter as a shoe company it will send to all the contacts. It would be OK but eventually my sock buyer who doesnt care about shoes may unsubscribe.Any ideas. Others like MC have a way to exclude right at last minute when I look at recipients?

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